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Patients with personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, diabetic retinopathy requiring treatment, or severe gastrointestinal disease require careful medical evaluation before initiation

European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes

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Research documents CNS-mediated mechanisms distinct from peripheral vascular pathways