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Similarly, the EXSCEL trial failed to show MACE superiority with exenatide, possibly due to high premature discontinuation rates [19]
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This is an underappreciated contributor to regain that rarely appears in mainstream stopping guides
Yes an aggressive or sustained calorie deficit can directly trigger binge eating episodes by raising ghrelin (the hunger hormone) and lowering leptin (the satiety hormone), creating powerful biological urges to overeat
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