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Some patients benefit from a gradual dose reduction rather than abrupt stopping, allowing appetite hormones to normalize gradually

The bottom line Newer GLP-1-based drugs can lead to powerful benefits for blood sugar, weight, and heart health, but nausea can make treatment unpleasant especially during the first few weeks of treatment or shortly after increasing the dose

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Talking to Your GP or Specialist About Weight Management Options Speak to your GP about licensed options such as semaglutide 2.4 mg (Wegovy) under NICE TA875 or tirzepatide (Mounjaro)

injections of 50 mol kg 1 memantine (n = 6 mice and n = 3 cages), 125 mol kg 1 memantine (n = 6 mice and n = 3 cages) or vehicle (isotonic saline, n = 6 mice and n = 3 cages) over 7 days

Semaglutide GLP-1 is part of a class of drugs known as glucagon-like-peptide 1 receptor antagonists, or simply GLP-1 receptor antagonists