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On that basis it says claims of synergy remain unvalidated and should not drive clinical decisions

doi: 10.1021/ja503710n

This methyl transfer is critical to reactions involving proteins, phospholipids, DNA, RNA, creatine, hormones, development of cell membranes, degradation of histamine, and formation of norepinephrine and dopamine

Wolk A, Gridley G, Svensson M, Nyrn O, McLaughlin JK, Fraumeni JF, et al

The cardiovascular protective effects of GLP-1RA involve multiple molecular mechanisms and signaling pathways