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Role of pycnogenol on other skin diseases: There are various mechanisms and biochemical pathways responsible for preventing and curing actions of herbal compounds such as induction of caspase activity, inhibition of angiogenesis and inhibition of the effects of other promoting proteins such as PI3-K, PKC, IKK, Bcl-2, AP-1, STAT3 and MMPs [75]

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While GHK has been shown to inhibit the inflammatory response and epithelial-mesenchymal transition (EMT) via the TGF-1/Smad 2/3 and IGF-1 pathways in bleomycin-induced fibrosis models [24], its broader anti-inflammatory effects in the context of pulmonary fibrosis pathogenesis may warrant further exploration

doi: 10.1183/13993003.00970-2022 39 CrookHRazaSNowellJYoungMEdisonP

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Collagen Renewal & Skin Texture Improvement GHK-Cu stimulates fibroblast activity and upregulates key regenerative genes, including TGF- and VEGF, supporting improved skin firmness, elasticity, and youthful volume