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Diabetic kidney disease substantially increases cardiovascular risk and the economic burden on healthcare systems ( 2 )the mortality rate increases significantly to 31.1% (95% CI, 24.7 to 37.5%) ( P = 0.003) ( The American Diabetes Association (ADA) and Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend annual screening for CKD starting 5 years or more after diagnosis in individuals with T1DM

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Metformin is the active ingredient in several type 2 diabetes medications and is available in both brand-name (like Glucophage) and generic forms, making it widely accessible and more affordable

10.1016/0006-291X(89)90797-3 Biochem

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