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While further interventional research is necessary, the current study adds to the growing evidence on the neurobehavioral benefits of GLP-1 RAs and supports their dual utility in managing both metabolic and psychiatric comorbidities

Experts recommend sticking with it for at least 4 or 5 months post-symptom relief to ensure lasting positive effects

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Patients should be advised that initial shedding may occur, and visible results typically require at least three to four months of consistent use

Three large CVOTs have been completed for the SGT2i in patients with T2DM: EMPA-REG OUTCOME (empagliflozin), CANVAS (canagliflozin), and DECLARE-TIMI 58 (dapagliflozin) (Table 1) (78,8388)

However, if your provider sees any evidence of heart disease (youve had a heart attack, a stroke, or you have peripheral vascular disease or congestive heart failure), then a GLP-1 should be started no matter your A1c