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For weight management, eligibility, nutrition support, tolerability, and long-term maintenance become central

Recent Findings In obesity, there is an imbalance in gut microbiota composition and low-grade chronic inflammation, which alters satiety control mechanisms, leading to increased intestinal permeability, resistance to leptin and insulin, ghrelin dysfunction, and dysregulation of dopamine, serotonin and neuropeptides (inclusing increased orexigenic NPY, and AgRP)

Similarly, fatigue that resurfaces when you increase doses typically resolves within 2 to 3 weeks at the new level

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This helps patients consume fewer calories and achieve weight loss