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In animal models, MOTS-c restored insulin sensitivity in aged and high-fat-fed mice at the muscle level - the same tissue where late-stage GLP-1 protocols often see metabolic slowdown
Tantu et al., 2025)
Systematic reviews and meta-analyses of randomized trials have further confirmed that while GLP-1RAs lower body weight and fat mass significantly, they do not appear to exert an independent detrimental effect on skeletal muscle index beyond expected proportional reductions [25]
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