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Basal energy expenditure was measured in a metabolic chamber, and did find a 97 calorie reduction per day in the intervention group

It may, in some patients

The impact of severe hepatic impairment (Child-Pugh Class C) on the pharmacokinetics of nirmatrelvir or ritonavir has not been studied

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Some patients express frustration that results are not immediate, and it can take weeks to months for the full effect

More important than sleep, stress management, or any other factor