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One of the major obstacles to developing biomarkers of intake for (poly)phenols seems to be the high inter-individual variability in absorption and metabolism reported, in particular for gut microbial metabolism (Reference Landberg, Manach and Kerckhof23)

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Weight reduction did not correlate with changes in the Appetite VAS scores

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For example, a 72-week phase II trial involving 320 patients with MASH, reported MASH resolution rates of up to 59% at the highest dose of 0.4 mg daily as compared to 17% in the placebo group

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