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Excessive iron levels can generate produce ROS via the Fenton reaction, activating various intracellular signaling pathways that enhance bone absorption and inhibit bone formation, thereby contributing to osteoporosis

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Beyond direct scavenging, L-Glutathione is the essential cofactor for a family of highly specialized antioxidant enzymes known as Glutathione Peroxidases (GPx)

The adaptive response of these pathogens to endogenous oxidative stress, as distinct from exogenous stressors, is a key area that requires further elucidation