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In the hypothalamus, the Sel1L-HRD1 complex is indispensable for proper leptin signaling and the folding of POMC, a precursor of neuropeptides that suppress appetite and regulate energy expenditure

GLP-1 medications can reduce alcohol cravings in some patients, which is worth discussing with your provider

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Whether these structural states are modulated by upstream regulatory signals, such as post-translational modifications or changes in cellular localization, remains to be determined

doi:10.3389/fnhum.2013.00192 Thapar A, Cooper M, Eyre O, Langley K

Whats more, few studies were at low risk of bias