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In the SURMOUNT-5 triala head-to-head, open-label, randomized controlled studytirzepatide (Zepbound) was compared to semaglutide (Wegovy) in adults with obesity or overweight and at least one comorbidity (e.g., hypertension, dyslipidemia, obstructive sleep apnea, or cardiovascular disease), but without type 2 diabetes.(11) At maximum tolerated doses over 72 weeks, Zepbound resulted in a mean weight reduction of 20.3%, compared to 13.2% with Wegovy.(11) Patients on the highest dose of tirzepatide and semaglutide reported nausea (31%, 14.4%) and diarrhea (23%, 14%).(9) Tirzepatide is currently the only FDA-approved pharmacotherapy to achieve this level of weight loss
And since insurance coverage for these therapies for weight loss has been spotty at best, many are left having to forego them, even when they need them
How long do I need to take tirzepatide
Dietary Adjustments Eat smaller, more frequent meals to reduce nausea
IV drips are more potent than oral capsules, which lose potency in the digestive tract