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243 In the local islet environment, a high concentration of somatostatin creates an inhibitory milieu, further reducing the activity of -cells and the secretion of glucagon

67 Turning to the insulin-related effects of GLP-1, it enhances insulin secretion and also affects insulin resistance through its effects, such as increasing the expression of glucose transporters in insulin-dependent tissues, and playing a role in lipid metabolism modulation, inflammation, and oxidative stress reduction

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