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This mechanism, which is observed in breast CAFs, as well as in luminal B (BT-474) and triple-negative (MDA-MB-231) breast cancer cells, but not in HER2 (SK-BR-3) and luminal A (MCF7) tumor cells, may contribute to angiogenesis in breast tumors [126]

The table below compares continuous daily dosing against the 5-on/2-off schedule across key protocol variables

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Of note, erythrocytes were found to contain cathepsin E, a mediator of peroxynitrite-induced cell death [262]