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Vigilancia de efectos adversos y advertencias importantes: El monitoreo debe incluir evaluacin de: Sntomas gastrointestinales: Nuseas, vmitos, diarrea, estreimiento, que aunque generalmente mejoran con el tiempo, pueden persistir en algunos pacientes

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In HBx-transgenic mice, alcohol causes higher acetaldehyde levels and more severe steatohepatitis by allowing HBx to bind and degrade mitochondrial ALDH2, reducing acetaldehyde clearance