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Diffusion tensor imaging shows reduced fractional anisotropy in white matter tracts ( In pediatric populations, congenital hypothyroidism and untreated iodine deficiency remain major causes of intellectual disability worldwide ( 3.3 Hyperthyroidism and neurological hyperactivity syndromes Hyperthyroidism, in contrast, produces a state of neural hyperexcitability ( Concurrently, T3 upregulates L-type calcium channels while reducing buffering proteins such as calbindin, creating a vulnerability to excitotoxicity ( 3.4 Thyroid-specific oxidative stress and neuroinflammation Oxidative stress and neuroinflammation are key mechanisms linking thyroid dysfunction to neuronal injury

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A rapid reduction in serum uric acid during urate-lowering therapy can destabilize crystal surfaces and trigger the release of proinflammatory substances

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