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It is most frequently considered for patients who have plateaued on semaglutide or tirzepatide, or where the additional metabolic dimension of glucagon receptor agonism is clinically justified

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PMID: 19533804

Mounjaro and Zepbound have a warning in their prescribing information that they may render birth control pills less effective

For example, the UK SmPCs for liraglutide (Saxenda) and semaglutide (Wegovy/Ozempic), available via the Electronic Medicines Compendium (eMC), advise awareness of heart rate increases during treatment and recommend that clinicians consider discontinuation if a clinically relevant sustained rise in resting heart rate is observed