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Interestingly, atypical Spitz tumor shares at least with PEM a peculiar biological behavior, featuring a high incidence of nodal metastases with a very low incidence of distant metastases (41, 47): such as unique biological property that strongly favors ultrasonograpy monitoring over sentinel node biopsy in the clinical management of such cases (47, 48)

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By modulating the epigenetic landscape, Epitalon may restore silencing of oncogenes or reactivate tumor suppressors in cells drifting toward dysplasia

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Perform a patch test and monitor for any adverse reactions before applying the serum to sensitive areas