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According to the FDA's press release it agreed to approve the drug for obesity based on three randomised, double-blind, placebo-controlled trials during which more than 2,600 patients received Wegovy for up to 68 weeks and more than 1,500 patients received placebo (US FDA 2021)

These elevations are typically mild and may not require treatment discontinuation unless accompanied by clinical symptoms

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Secondary endpoint outcome : 32.7% of semaglutide vs 16.1% in placebo reported combined resolution of steatohepatitis and reduction in liver fibrosis (difference of 16.5%

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