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Use outside the approved indication is off-label, which is a legitimate physician decision made patient by patient, with the reasoning documented and discussed

Together, excessive and reduced production of neuro-toxic and -protective kynurenines, respectively, may exacerbate excitotoxicity and neuroinflammation, establishing a feed-forward cycle of KP dysregulation, 5-HT depletion, HPA axis hyperactivity, and increased vulnerability to MDD

Voitenleitner, C., Bechtel, J., Arfsten, A

& Sullenger, B