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Within the physiologically plausible range of cerebral blood flow, the brain concentration of 7,8-DHF is not sensitive to changes in cerebral blood flow

Oxidative stress can cause abnormal expression of various inflammatory markers, resulting in mitochondrial dysfunction and aberrant cellular energy metabolism, further increasing the joint burden and exacerbating joint damage [6, 7]

Meta-analysis of 7 CVOT pooled demonstrated that GLP-1RAs were associated with a similar decrease in MACE regardless of gender [50]

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