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In the SURPASS-6 trial, TZP was compared to insulin Lispro three times daily in diabetic patients previously treated with a dose of insulin glargine, with or without metformin
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Many factors, such as the interruption of the estradiol cycle and the increase of inflammatory cytokines, will lead to changes in synaptic function and morphology, which may be one of the pathogenesis of depression (138)
However, when compared with baseline, SBP did not appreciably change after treatment with ALC whereas it significantly decreased in patients allocated to placebo (from 138.1 18.3 mm Hg to 134.5 15.1 mm Hg
