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Our most advanced candidate, danuglipron, has shown good efficacy in a twice-daily formulation, and we believe a once-daily formulation could be highly competitive in the oral GLP-1 space, said Mikael Dolsten, MD., PhD., Chief Scientific Officer & President, Pfizer Research and Development

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In particular, long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) can cause gastric mucosal damage as they can inhibit mitochondrially encoded cytochrome C oxidase I (MT-CO1, also known as COX-1) and block its protective effect on gastric mucosa

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