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In turn, endothelial cell dysfunction affects the synthesis and secretion of the glycocalyx, thereby forming a vicious circle (58)

While animal studies consistently demonstrate beneficial effects across diverse injury models and tissue types, the absence of adequately powered, controlled human clinical trials prevents definitive conclusions about efficacy in human disease

The published mechanistic literature has converged on the HGF/c-Met receptor system as the primary molecular target, with downstream effects on dendritic synaptogenesis and PI3K/AKT signaling

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