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doi: 10.1136/annrheumdis-2017-212257 179 CappelliLCGutierrezAKBinghamCO3rdShahAA
Subcutaneous injection Subcutaneous injection remains the most common and well-studied administration route for DSIP
Cholinergic neurons of the enteric nervous system, which interact closely with gastrointestinal epithelial cells, as well as ACh signaling in non-neuronal cells such as enteric glia and pancreatic cells, depend on the essential role of thiamine in ACh production and the facilitation of ACh signaling
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As with irisin, METRNLs receptor has not been definitively identified, limiting conventional drug development strategies
Human evidence outside EPP remains limited or investigational
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