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In the SURPASS-2 diabetes trial, an open-label 40-week study randomised 1,879 patients with type 2 diabetes to tirzepatide 5, 10, or 15 mg or to semaglutide 1 mg

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[15] Methodological issues with the clinical trials prevent firm conclusions, and the review authors stated: "No definitive conclusion can currently be drawn" and there is "no definitive evidence that MSM is superior to placebo in the treatment of mild to moderate osteoarthritis of the knee." [16] Contraindications and safety [edit] In July 2007 a manufacturer of MSM submitted a notification to the U } : CS1 maint: DOI inactive as of July 2025 (link) Oyo Yakuri Pharmacometrics