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S.et al (2018)
Copyright Mars or Affiliates and the Author(s), 2024
The lungs, where the exchange and presence of oxygen is continuous, are particularly vulnerable to reactive oxidative species (ROS), which at excessive levels could overwhelm the availability of antioxidants culminating in oxidative stress
Epub 2005 Feb 17
For tendinopathies, this distinction is critical since corticosteroids can weaken already compromised tendons
Evidence showed that excess intracellular hydrogen peroxide regulates the expression of various NF-B component proteins, and the alterations in the composition or quantity of the NF-B dimer can change down-stream target gene expression, and conduce to the upregulation of pro-inflammatory genes and a pro-apoptotic environment ( In summary, we investigated the role of GPX1 in protecting SGNs against oxidative stress by upregulating or inhibiting the expression of GPX1 in SGNs via the GPX1 mimic ebselen or the gpx1 knockout mouse model, and further determined the mechanistic details behind the neuroprotective effect of GPX1 in SGNs against peroxynitrite injury
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