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Understanding why GLP-1 therapy affects heart rate requires examining both the direct pharmacological actions of these medications and their indirect metabolic and hemodynamic effects on the cardiovascular system

GLP-1 medications may reduce liver fat and improve liver enzymes, helping lower the risk of complications such as fibrosis, cirrhosis and liver cancer

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During the innate immune response, neutrophils respond by releasing a burst of ROS (and MPO)

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A triple-action therapy (GIP + GLP-1 + Glucagon) currently under investigation, demonstrating up to ~24% weight reduction in early trials