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Amylin receptor activation requires far less compound than simultaneous triple receptor agonism

Ghouri, A

Only one small cluster (category II-D), such as SUDS3 S32 and CPD T1365 , was unequally regulated between insulin and IGF-1 stimulation (Supplemental Figure 2, D and E), suggesting that for some actions, there may be differential effects based on whether insulin or IGF-1 occupies the receptor

Patient ambulates with a cane, reports generalized weakness and deconditioning, and has poor exercise tolerance with limited endurance