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Surprisingly, in Obese ChR2 mice ( Fig 5D , red trace), the 2 mg/kg dose of tesofensine failed to dampen the surge in sucrose intake triggered by optogenetic stimulation compared to saline (p 0.3, n.s.)

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Then, in the days leading up to the hearing, controversy surrounding these new industry-connected panelists prompted the FDA to again add eight new experts to the hearing, bringing the total number of voting individuals to 14