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Analysis of cohorts Our meta-analysis included four studies

[DOI] [PubMed] [Google Scholar] 61.Cui X, Zhu Y, Zeng L, Zhang M, Uddin A, Gillespie TW, McCullough LE, Zhao S, Torres MA, Wan Y

Early action = better outcomes

Lastly, most trials (and observational studies) did not consider duration of diabetes as an eligibility criterion or account for this by subgroup analyses

But glycogen depletion is only part of the picture

Other recognised effects include injection site reactions, and rarely, acute pancreatitis, gallbladder disease, or diabetic retinopathy complications with rapid glucose improvement