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Anti-TNF- agents (infliximab, adalimumab) remain first-line options, significantly reducing intestinal inflammation by blocking TNF-
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Second, it plays a role in preventing misuse and abuse, as individuals may attempt to use hydrocodone without a prescription or inappropriately combine it with other substances
A larger follow-up RCT (n=72 older adults) confirmed these findings, additionally demonstrating improvements in gait speed (+0.14 m/s), grip strength, 6-minute walk distance, waist circumference reduction, and systolic blood pressure reduction (Kumar et al., J Gerontol A Biol Sci Med Sci, 2023) [21]