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Patients also reported feeling more satisfied with their overall appearance, leading to increased self-esteem and greater personal accomplishment

The tissues were counterstained with the Harris hematoxylin and mounted in Entellan

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Mitochondrial zinc dysregulation A key consequence of mitochondrial dysfunction is the overproduction of ROS, which damage proteins, lipids, DNA and organelles

These patients stand to benefit the most from significant weight reduction

To evaluate this combination, we used the Zero Interaction Potency (ZIP) model, which accounts for independent drug effects and is particularly suited for combinations of agents with differing targets, such as DPI and vincristine (38)