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These patients typically have low levels of folate in both plasma and CSF, and they may exhibit abnormally high urinary metformin glutamate excretion [115]

Available treatments such as levodopa, dopamine agonists and monoamine oxidase B inhibitors offer only symptomatic relief however, they do not treat the underlying neurodegeneration, emphasising the need for neuroprotective management

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n=36 healthy subjects, teduglutide 4 mg/day for 10 days

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