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Notably, induction of HO-1 expression alleviated diabetic neuropathic pain and facilitated modulation of the diabetic nerve functions [61, 62]

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Similarly, the GLP-1R/GIPR/GcgR triple-agonists in phase I clinical trials represent a promising horizon of therapeutic utility, in which the body weight-lowering and glycemia-correcting synergies associated with simultaneous agonism of all three receptors seem to outpace the benefits of the well-developed GLP-1R/GIPR dual-agonists