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These results are backed up by the finding of a strong increase of the concentration of Pycnogenol s metabolites and components in the synovial fluid, surrounding articular cartilage in the joints in osteoarthritis patients (71, 72)

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385,386,387 Many CSF biomarkers (like A, P-tau, NfL, GFAP) also show promising applications in blood, with advancements in highly sensitive analytical platforms and detection techniques enhancing diagnostic precision and reliability