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Additionally, because low NAD+ is linked to aging, its decline could contribute to the development of various age-related health concerns, including cardiovascular disease, metabolic disorders, the development of neurodegenerative diseases such as Alzheimers and Parkinsons, and cancer

J Hepatobiliary Pancreat Surg 14(1):1526

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Similarly, SLC7A11 can be upregulated by LAPTM4B to inhibit ferroptosis or downregulated by circPOLA2 to promote it (35), yet the contextual switches governing its function are unknown