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Conclusion: We highlight the critical role of adequate short-term prophylaxis in the pre-procedural management of HAE patients undergoing attack-triggering interventions, including surgical procedures

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No significant heterogeneity among studies ( I 2 = 33%, p =0.18), so the fixed-effects model was used to combine the effect sizes

A compound may lose most of its active effects relatively quickly while traces remain detectable for a longer period