The unprecedented demand for glucagon-like peptide-1 (GLP-1) receptor agonists, specifically semaglutide and tirzepatide, has transformed what was once a niche practice of customized medication into a multi-billion-dollar shadow industry
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Cardiovascular circulation is already elevated from the heat, stress hormones drop, and then the massage pushes that further
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Patients with controlled uric acid level and doing well on allopurinol would seem to have no reason to switch to this new agent, in view of allopurinol's lower cost and 40-year history of an overall very good safety record (see "Allopurinol" discussion above)
It established that semaglutide reduces cardiovascular risk independent of blood sugar control