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Rodrigues T, Piccirillo S, Magi S, Preziuso A, Dos Santos Ramos V, Serfilippi T et al (2022) Control of Ca(2+) and metabolic homeostasis by the Na(+)/Ca(2+) exchangers (NCXs) in health and disease
The amidated C-terminal residue differs across CT-family peptides and this residue forms the only direct contact with RAMPs in previously reported AMYR complexes 15,16
MOTS-c is typically administered subcutaneously at doses ranging from 515 mg per administration in rodent models, scaled to body weight and metabolic baseline
A monoamine oxidase (MAO)-inhibiting agentmoclobemideis susceptible to UV-C irradiation which leads to formation of 4-chlorobenzamide as a main degradant and two other photoproducts as a consequence of morpholine ring cleavage (Skibiski and Komsta 2012)
This diversity enables phenotypic switching and escape from single-target approaches
This is a significant, sometimes dramatic shift
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