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Table 1 : Fictitious Example (If a patient has an estriol of 2, an estrone of 2, a 16 a-OHE1 of 2, and an estradiol of 2, then the Total Estrogen Effect (TEE) would be 48 based on their relative binding affinities) **Although 16a-OHE1 is a Phase I metabolite, it is included in the calculation due to its ability to contribute to estrogen dominance

meaning as the excretion of these metabolites increased, the clinical scores decreased indicating behavioral improvement (Bent et al., 2018)

10.1124/mol.62.5.1001 105 KaurM.BaggaP

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10.5483/BMBRep.2025-0019 39 LinQ.GuanS.PengM.ZhangK.ZhangH.MoT.et al (2025)