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The trivalent iron (Fe 3+ ) is not bioavailable and needed to be reduced into ferrous form (Fe 2+ ) by duodenal cytochrome b (DcytB), which is then absorbed into enterocytes by the divalent metal transporter-1 (DMT1) in the apical surface of enterocytes [26]

Electrophoresis utilises electric fields to enhance the migration of charged molecules, such as liposomal carriers, by augmenting skin permeability and facilitating active transdermal transport [241,242,243]

The ADC approach could offer a second life to drugs presenting a high cytotoxicity or a lack of selectivity (Fig

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