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Some people report improved energy, sleep, lean body mass, and overall vitality, though robust clinical evidence for anti-aging effects is lacking and remains controversial

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Recently, Chen et al (187) developed a folic acid-decorated, manganese dioxide-coated mesoporous silica nanoparticle to co-deliver fluvastatin sodium (MCT4 inhibitor) and metformin, effectively targeting tumor lactate metabolism by promoting lactate production and inhibiting lactate efflux, thereby exacerbating intracellular acidosis and inducing cancer cell death

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However, the side effects and continued high cost of these medications present significant access barriers, limiting their potential public health impact

M.ConradR.BistaP.et al (2011)