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5 A recent cohort study of NAD+ and a proprietary combination of B vitamins, amino acids, and DL-phenylalanine (an enkephalinase inhibitor) IV for substance abuse disorder found statistically significant improvement in cravings, anxiety, and depression scores for patients on IV NAD+.5 Another study on patients with alcohol or opiate addiction found doses of 500-1500mg per day (in combination with some vitamins, amino acids, and n-acetylcysteine) for 10 days to reduce cravings and number of relapses when patients were surveyed 12-20 months post treatment

It has also shown success in Phase II trials for ophthalmic repair and dry eye

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Gutzwiller JP, Degen L, Matzinger D, Prestin S, Beglinger C

At 0.1 mg weekly, steady-state concentrations would be proportionally lower (approximately 5 nmol/L) but still within a pharmacologically active range based on in vitro receptor binding data

others continue operating in a gray zone with unreliable supply and high legal risk