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Abstract Introduction: Oxidative stress has been implicated in psychiatric disorders, including posttraumatic stress disorder (PTSD)

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doi: 10.1152/ajpcell.00141.2016

Bruce [ACS Chemical Biology, 2010, vol

Eight weeks of aerobic exercise significantly activated the System Xc /GPx4 signaling pathway in the prefrontal cortex of APPswe/PS1dE9 transgenic AD mice, up-regulated FTL and BACE1 expression, significantly downregulated 4-HNE levels, inhibited oxidative stress, lipid peroxidation, and ferroptosis, reduced A positivity, alleviated neuronal morphological abnormalities, and improved learning and memory functions in AD mice (Li et al., 2024a)

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