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363 An elegant study in wild-type mice demonstrated that chronic stress combined with a high-fat diet results in insulin derepression of NPY neurons in the central amygdala, thereby causing exaggerated obesity and hyperinsulinemia

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Phase 2 dose-finding trial Published in The Lancet in 2021, this multicenter, randomized, double-blind trial tested cagrilintide doses ranging from 0.3 mg to 4.5 mg weekly in people with overweight or obesity

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