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The FDA has sent three waves of warning letters to telehealth companies marketing compounded GLP-1s since September 2025, most recently 25 letters in June 2026, citing misleading claims that the product is the same as the FDA-approved drug and sellers that never disclose which pharmacy made the medication

In the STEP 1 trial, participants receiving semaglutide 2.4 mg lost an average of 14.9% of their body weight over 68 weeks

That said, everyone responds differently to these medications

This early window is when your GLP-1 receptors begin responding to the medication, signaling fullness to your brain and slowing gastric emptying

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Cell 186 , 732747 e716 (2023)