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[PubMed ID: 16389274]

Changes in cellular morphology were assessed qualitatively

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When expressed in the CHO cell line, the hKOR was demonstrated to undergo a time- and concentration-dependent uncoupling from G proteins but with a moderate impact on the inhibition of ACase (a two-fold increase of the EC 50 value of the KOR agonist U50488) (Zhu et al., 1998)

Administered via 250ml normal saline infusion